3D CAD with horizontal size compensation?

[draj]

Is there any CAD programs which can apply a Horizontal size compensation (Simplify3D), XY size compensation (Slic3r), to the .STL model itself?
This is a very important feature for me, which is limiting me to these slicers and I would need to use MakerBot because of the printer...

[ednisley]

Is there any CAD programs which can apply a Horizontal size compensation

The term "CAD" usually refers the program you use to sculpt / define a solid model. The CAD program exports an intermediate geometry file (the STL or AMF file used for 3D printing) that's generally regarded as "read only" because it doesn't contain any of the design parameters.

You're probably looking for a "mesh editor" (like Meshlab) that can read an arbitrary STL file, apply various transformations (including scale factors) to the mesh, and save the modified mesh as a new STL file. Most mesh editors have GUI interfaces that require manual point/click/type action.

Slic3r (and presumably S3D) can apply a limited number of transformations, including scaling, to an STL / AMF geometry file and export the resulting STL file. That might suffice for your purposes.

If you must modify many STL files, you can write a script to drive OpenSCAD; it can import / adjust / export STL files without human intervention. Huge STL files may pose a problem, but that's true for most mesh editors.