Short answer, yes, you can start with the M2 24V V4 profile. Longer, spammed answer:
We're working on getting all of our documentation in one place - the Zendesk Help Center which will tie-in nicely with existing support - and linked in the proper locations on the website. As the first video below says, we are working on getting the M3 S3D profile bundled with S3D, but our update schedules didn't quite line up so it will take a bit of time.
You can find a video on how to use Simplify3D with your M3 here:
https://makergear.zendesk.com/hc/en-us/ ... D-WorkflowYou can also find more info about on-board slicing in OctoPrint in these 2 articles/videos:
https://makergear.zendesk.com/hc/en-us/ ... al-object-https://makergear.zendesk.com/hc/en-us/ ... e-and-more